Review Article

Investigation of radiation attenuation parameters of some drugs used in Chemotherapy in Wide Energy Region

Ferdi Akman* and Mustafa Recep Kaçal

Published: 04 August, 2018 | Volume 2 - Issue 2 | Pages: 047-052

Objectives: The aim of this study is to compute the radiation attenuation parameters such as mass attenuation coefficient, linear attenuation coefficient, half value layer, mean free path, and effective atomic number for some selected chemotherapy drugs such as Lomustine, Cisplatin, Carmustine, and Chlorambucil in the energy range from 1 keV to 100 GeV.

Materials and Methods: The mass attenuation coefficients were calculated with the help of WinXCOM program. Using the obtained mass attenuation coefficients, other parameters such as linear attenuation coefficient, half value layer, mean free path, and effective atomic number were derived.

Results: It is observed that the variations of these parameters with respect to the photon energy show changes in different energy regions. According to the obtained results, Cisplatin has the highest mass attenuation coefficient, linear attenuation coefficient and effective atomic number results among the selected chemotherapy drugs. Moreover, Chlorambucil has the highest half value layer and mean free path results among the selected chemotherapy drugs.

Conclusion: The results of this study are useful for applied science fields such as radiation physics, pharmacology, and medical physics. These results may be useful when the selected chemotherapy drugs are used together with radiology.

Read Full Article HTML DOI: 10.29328/journal.jro.1001021 Cite this Article Read Full Article PDF


Chemotherapy drug; Mass attenuation Coefficient; Linear attenuation Coefficient; Half value layer; Mean free path; Effective atomic number


  1. National Institutes of Health, 2012.
  2. Weiss RB, Issell BF. The nitrosoureas: carmustine (BCNU) and lomustine (CCNU). Cancer Treat Rev. 1982; 9: 313-330. Ref.: https://tinyurl.com/y8qdebfs
  3. Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014; 740: 364-378. Ref.: https://tinyurl.com/ycxfuo7r
  4. Bodnar EN, Dikiy MP, Medvedeva EP. Photonuclear production and antitumor effect of radioactive cisplatin (195mPt). J Radionan Nucl Ch. 2015; 305: 133-138. Ref.: https://tinyurl.com/ycwcen5h
  5. Akman F, Durak R, Kacal MR, Bezgin F. Study of absorption parameters around the K edge for selected compounds of Gd. X-ray Spectrom. 2016; 45: 103-110. Ref.: https://tinyurl.com/yapxhshz
  6. Akman F, Durak R, Turhan MF, Kacal MR. Studies on effective atomic numbers, electron densities from mass attenuation coefficients near the K edge in some samarium compounds. Appl Radiat Isotopes. 2015; 101: 107-113. Ref.: https://tinyurl.com/yba3c4bx
  7. Sayyed MI. Half value layer, mean free path and exposure buildup factor for tellurite glasses with different oxide compositions. J Alloy Compd. 2017; 695: 3191-3197. Ref.: https://tinyurl.com/yaehr6zn
  8. Akman F, Durak R, Kacal MR. Determination of K shell absorption parameters for some lanthanides using the X-ray attenuation method. Can J Phys. 2015; 93: 1532-1540. Ref.: https://tinyurl.com/yctgdyjp
  9. Kaçal MR, Karataş HA, Akman F. Photon absorption characteristics of some selected enzyme inhibitors used in cancer research in the energy range 1 keV-100 GeV. J Radiol Oncol. 2017; 1: 60-68. Ref.: https://tinyurl.com/yd36ejhb
  10. Akman F, Kaçal MR, Akman F, Soylu MS. Determination of effective atomic numbers and electron densities from mass attenuation coefficients for some selected complexes containing lanthanides. Can J Phys. 2017; 95: 1005-1011. Ref.: https://tinyurl.com/y9y32rjm
  11. Akman F, Kaçal MR, Durak R. Chemical effect on the K shell absorption parameters of some selected cerium compounds. J Instrum. 2016; 11: P08006. Ref.: https://tinyurl.com/ybmuet9x
  12. Kacal MR, Han I, Akman F. Measurement of mass attenuation coefficients by Si (Li), NaI (Tl), and Cd (Tl) detectors. Nuclear Science and Technology. 2012: 59-69. Ref.: https://tinyurl.com/y7u2qgx2
  13. Sayyed MI, Issa SAM, Auda SH. Assessment of radio-protective properties of some anti-inflammatory drugs. Prog Nucl Energ. 2017; 100: 297-308. Ref.: https://tinyurl.com/ycfc6s9y
  14. Akman F, Geçibesler IH, Sayyed MI, Tijani SA, Tufekci AR, et al. Determination of some useful radiation interaction parameters for waste foods. Nucl Eng Technol. 2018; 50: 944-949. Ref.: https://tinyurl.com/ybtqtw2z
  15. Akman F, Geçibesler İH, Demirkol İ, Çetin A. Determination of effective atomic numbers and electron densities for some synthesized triazoles from the measured total mass attenuation coefficients at different energies. Can J Phys. Ref.: https://tinyurl.com/y7w8sgny
  16. Gerward L, Guilbert N, Jensen KB, Levring H. X-ray absorption in matter: Reengineering XCOM. Radiat Phys Chem. 2001; 60: 23-24. Ref.: https://tinyurl.com/y8v5yhz3
  17. Kavaz E, Ahmadishadbad N, Özdemir Y. Photon buildup factors of some chemotherapy drugs. Biomed Pharmacother. 2015; 69: 34-41. Ref.: https://tinyurl.com/y7858kgj


Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Figure 1

Figure 4

Figure 1

Figure 5

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More