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Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications

Loutfy H Madkour*

Published: 04 March, 2021 | Volume 5 - Issue 1 | Pages: 005-034

Multimodality in vivo imaging of RNAi by using MRI and optical imaging. (a) Schematic illustration of the multifunctional nanocarriers with core of magnetic nanoparticles, and surface conjugated with Cy5.5, GFP siRNA (siGFP), and membrane translocation peptides (MPAP). (b) in vivo MR imaging of mice bearing with subcutaneous LS174T human colorectal adenocarcinoma tumors (arrows) before and after the administration of the multifunctional nanocarriers, indicating significant drop of T2-weighted contrast enhancement in tumor regions after injection of the contrast agents. (c) A high-intensity NIRF signal in the tumor confirmed the successful delivery of the nanocarriers, while the left mouse with white light, middle one with NIRF, and right one with color-coded overlay. Adapted with permission from [175].

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Figure 0:

Multimodality in vivo imaging of RNAi by using MRI and optical imaging. (a) Schematic illustration of the multifunctional nanocarriers with core of magnetic nanoparticles, and surface conjugated with Cy5.5, GFP siRNA (siGFP), and membrane translocation peptides (MPAP). (b) in vivo MR imaging of mice bearing with subcutaneous LS174T human colorectal adenocarcinoma tumors (arrows) before and after the administration of the multifunctional nanocarriers, indicating significant drop of T2-weighted contrast enhancement in tumor regions after injection of the contrast agents. (c) A high-intensity NIRF signal in the tumor confirmed the successful delivery of the nanocarriers, while the left mouse with white light, middle one with NIRF, and right one with color-coded overlay. Adapted with permission from [175].

Read Full Article HTML DOI: 10.29328/journal.jro.1001035 Cite this Article Read Full Article PDF

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