Figure 4

Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications

Loutfy H Madkour*

Published: 04 March, 2021 | Volume 5 - Issue 1 | Pages: 005-034

in vivo pharmacokinetics, NIR imaging and bio distribution studies. (A) in vivo pharmacokinetics of PTX/HAI-NGs and free PTX in mice. PTX level is expressed as % injected dose per gram of tissue (%ID/g). Data are presented as mean ± SD (n = 3); (B) in vivo fluorescence images of MCF-7 human breast tumor bearing nude mice at different time points following tail vein injection of Cy5-loaded nanogels. Circled areas indicate the locations of the tumor. PTX level, expressed as % injected dose per gram of tissue (% ID/g), in the tumor and different organs after 6 or 12 h post injection of PTX/HAI-NGs (C) or free PTX (D). Data are presented as mean ± SD (n = 3).

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Figure 4:

in vivo pharmacokinetics, NIR imaging and bio distribution studies. (A) in vivo pharmacokinetics of PTX/HAI-NGs and free PTX in mice. PTX level is expressed as % injected dose per gram of tissue (%ID/g). Data are presented as mean ± SD (n = 3); (B) in vivo fluorescence images of MCF-7 human breast tumor bearing nude mice at different time points following tail vein injection of Cy5-loaded nanogels. Circled areas indicate the locations of the tumor. PTX level, expressed as % injected dose per gram of tissue (% ID/g), in the tumor and different organs after 6 or 12 h post injection of PTX/HAI-NGs (C) or free PTX (D). Data are presented as mean ± SD (n = 3).

Read Full Article HTML DOI: 10.29328/journal.jro.1001035 Cite this Article Read Full Article PDF

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