Figure 1

Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications

Loutfy H Madkour*

Published: 04 March, 2021 | Volume 5 - Issue 1 | Pages: 005-034

1: Illustration of bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors. (a) PTX-loaded HAI-NGs are prepared via nanoprecipitation followed by crosslinking via UV irradiation; (b) PTX-loaded HAI-NGs actively target and accumulate at MCF-7 tumors, resulting in enhanced CT contrast and targeted therapy; (c) PTX-loaded HAI-NGs are selectively internalized into the MCF-7 breast tumor cells via CD44 receptor-mediated endocytosis, nanogels are decross linked and disassembled in response to GSH in the cytosol, and PTX is quickly released into the cells.

" alt="jro-aid1035-s001"class="img-responsive img-rounded " style="cursor:pointer">

Figure 1:

1: Illustration of bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors. (a) PTX-loaded HAI-NGs are prepared via nanoprecipitation followed by crosslinking via UV irradiation; (b) PTX-loaded HAI-NGs actively target and accumulate at MCF-7 tumors, resulting in enhanced CT contrast and targeted therapy; (c) PTX-loaded HAI-NGs are selectively internalized into the MCF-7 breast tumor cells via CD44 receptor-mediated endocytosis, nanogels are decross linked and disassembled in response to GSH in the cytosol, and PTX is quickly released into the cells.

Read Full Article HTML DOI: 10.29328/journal.jro.1001035 Cite this Article Read Full Article PDF

More Images

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?