Radiation Effects on Malignant Bone Tumors: A Comprehensive Review
Article Sidebar
Main Article Content
Abstract
Malignant bone tumors, including osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma, are rare but aggressive cancers requiring multimodal therapy. While surgery and chemotherapy remain the primary treatments, radiation therapy plays a critical role in cases of incomplete resection, inoperable tumors, or tumors located near vital structures. This review examines the biological effects of radiation, clinical applications, complications, and future directions in the management of malignant bone tumors, with added emphasis on surgical context, treatment comparisons, and emerging molecular insights such as the role of Sirtuin 1.
Article Details
Copyright (c) 2026 Abdelnoor J.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Sun M, Du M, Zhang W, Xiong S, Gong X, Lei P, et al. Survival and clinicopathological significance of SIRT1 expression in cancers: a meta-analysis. Front Endocrinol (Lausanne). 2019;10:121. Available from: https://doi.org/10.3389/fendo.2019.00121
Iftikhar M, Tanveer S, Abrar S, Rehman A, Ahmad S, Saddozai UAK, et al. Correlation between SIRT1 expression and overall survival across various cancers: a meta-analysis. Gene Protein Dis. 2025;[Epub ahead of print]. Available from: https://accscience.com/journal/GPD/4/1/10.36922/gpd.4294
Simmons GE Jr, Pruitt WM, Pruitt K. Diverse roles of SIRT1 in cancer biology and lipid metabolism. Int J Mol Sci. 2015;16(1):950-965. Available from: https://doi.org/10.3390/ijms16010950
DeLaney TF, Liebsch NJ, Pedlow FX, Adams J, Weyman EA, Yeap BY, et al. Long-term results of proton therapy for chordomas and chondrosarcomas of the skull base and spine. Clin Cancer Res. 2019;25(16):5165-5177. Available from: https://doi.org/10.1002/jso.23617
Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base report. J Bone Joint Surg Am. 2007;89(1):34-48. Available from: https://doi.org/10.1097/blo.0b013e318059b8c9
Qin H, Zhang H, Zhang S, Zhu S, Wang H. Protective effect of SIRT1 against radiation-induced damage. Radiat Res. 2021;196(6):647-657. Available from: https://doi.org/10.1667/rade-20-00139.1
Bölling T, Dirksen U, Meyer-Heim A. Radiotherapy in Ewing sarcoma: indications and results. Cancer Radiother. 2015;19(8):727-735.
Uhl M, Mattke M, Welzel T. Carbon ion therapy for chordomas and chondrosarcomas. Radiother Oncol. 2014;111(2):187-192.