Metastatic Brain Melanoma: A Rare Case with Review of Literature
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Abstract
Melanoma is a highly malignant neoplasm arising from melanocytes, which are melanin-producing neural crest cells primarily located in the basal layer of the epidermis, making cutaneous melanoma the most common subtype. However, melanocytes are also found in other anatomical locations, and primary non-cutaneous melanomas, though rare, have been documented. Due to the aggressive nature of this malignancy, it carries a poor prognosis, particularly because it tends to metastasize to various, often atypical, sites. Recognizing these variable presentations is essential for timely diagnosis. Here, we report a rare case of metastatic brain melanoma in a young female and review the relevant literature, highlighting the importance of imaging in identification.
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Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death. Lancet. 2016;388:1459–1544. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31012-1/fulltext
Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001;19(16):3635–48. Available from: https://doi.org/10.1200/jco.2001.19.16.3635
Barden H, Levine S. Histochemical observations on rodent brain melanin. Brain Res Bull. 1983;10(6):847–51. Available from: https://doi.org/10.1016/0361-9230(83)90218-6
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. Available from: https://doi.org/10.3322/caac.21763
Johnson DB, Puzanov I. Treatment of brain metastases in the modern era. Am Soc Clin Oncol Educ Book. 2014:e363–9.
Fife KM, Colman MH, Stevens GN, Firth IC, Moon D, Shannon KF, et al. Determinants of outcome in melanoma patients with cerebral metastases. J Clin Oncol. 2004;22(7):1293–300. Available from: https://doi.org/10.1200/jco.2004.08.140
Nayak L, Lee EQ, Wen PY. Epidemiology of brain metastases. Curr Oncol Rep. 2012;14(1):48–54. Available from: https://doi.org/10.1007/s11912-011-0203-y
Davies MA, Liu P, McIntyre S, Kim KB, Papadopoulos N, Hwu WJ, et al. Prognostic factors for survival in melanoma patients with brain metastases. Cancer. 2011;117(8):1687–96. Available from: https://doi.org/10.1002/cncr.25634
Isiklar I, Leeds NE, Fuller GN, Kumar AJ. Intracranial metastatic melanoma: correlation between MR imaging characteristics and melanin content. AJR Am J Roentgenol. 1995;165(6):1503–12. Available from: https://doi.org/10.2214/ajr.165.6.7484597
Ginaldi S, Wallace S, Shalen P, Luna M, Handel S. Cranial computed tomography of malignant melanoma. AJR Am J Roentgenol. 1981;136(1):145–9. Available from: https://doi.org/10.2214/ajr.136.1.145
Schellinger PD, Meinck HM, Thron A. Diagnostic accuracy of MRI compared to CCT in patients with brain metastases. J Neurooncol. 1999;44(3):275–81. Available from: https://doi.org/10.1023/a:1006308808769
Reddy VU, Suneetha P, Shanthi V, Mohan KV, Agrawal A. Intracranial hemorrhagic metastases as the first manifestation of an occult melanoma. South Asian J Cancer. 2015;4(2):101–2. Available from: https://doi.org/10.4103/2278-330x.155705
Glitza Oliva IC, Tawbi HA, Davies MA. Safety and activity of combination immunotherapy with nivolumab plus ipilimumab in patients with melanoma brain metastases: real-world experience. J Neurooncol. 2021;153(1):127–34.
Wronski M, Arbit E. Surgical treatment of brain metastases from melanoma: a retrospective study of 91 patients. J Neurosurg. 2000;93(1):9–18. Available from: https://doi.org/10.3171/jns.2000.93.1.0009
Sperduto PW, Jiang W, Brown PD, Braunstein S, Sneed P, Wattson DA, et al. Estimating survival in melanoma patients with brain metastases: An update of the Graded Prognostic Assessment for melanoma using molecular markers (Melanoma-molGPA). Int J Radiat Oncol Biol Phys. 2017;99(4):812–6. Available from: https://doi.org/10.1016/j.ijrobp.2017.06.2454
Vágó Z, Tóvári J. Advances in targeted therapy and immunotherapy for melanoma brain metastases. Cancer Metastasis Rev. 2022;41(1):81–97.
Sampson JH, Carter JH, Friedman AH, Seigler HF. Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma. J Neurosurg. 1998;88:11–20. Available from: https://doi.org/10.3171/jns.1998.88.1.0011
Bryne TN, Cascino TL, Posner JB. Brain metastasis from melanoma. J Neurooncol. 1983;1(4):313–7. Available from: https://doi.org/10.1007/bf00165714