Case Report

A Short Synthesis Concerning Biological Effects and Equivalent Doses in Radiotherapy

Cyril Voyant*, Cyril Voyant* and Daniel Julian

Published: 15 April, 2017 | Volume 1 - Issue 1 | Pages: 039-045

The limits of classical equivalent computation based on time, dose, and fractionation (TDF) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. In this letter, we propose an outline related to the different models usable for equivalent and biological doses that are likely to be the most appropriate. The used methodology is based on: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames.

Read Full Article HTML DOI: 10.29328/journal.jsmt.1001036 Cite this Article Read Full Article PDF


Radiobiology; Fractionation; Equivalent; Dose; Time effect; Linear quadratic; Repopulation


  1. Spotheim-Maurizot M, Mostafavi M, Belloni J, Douki T. Radiation chemistry: from basics to applications in material and life sciences. L’Editeur : EDP Sciences; 2008.
  2. Deutsch E, Vozenin MC. La radiobiologie, une discipline d’interface. Cancer Radiothér. 2011; 15: 347. Ref.: https://goo.gl/0rdTBi
  3. Steel GG. Basic Clinical Radiobiology. 3rd Revised edition. Hodder Arnold. 2002.
  4. Joubert A, Vogin G, Devic C, Granzotto A, Viau M, et al. Biologie des radiations. avancées majeures et perspectives pour la radiothérapie. Cancer Radiothér. 2011; 15: 348-354. Ref.: https://goo.gl/s2ISQL
  5. Foray N. Aspects radiobiologiques des traitements anticancéreux par rayonnement synchrotron: bilan et perspectives. Cancer/Radiothérapie. 2010; 14: 145-154. Ref.: https://goo.gl/E1TDTi
  6. Bourgier C, Heymann S, Vielh P, Azria D. Implications radiobiologiques de la classification moléculaire des cancers du sein: présent ou avenir? Cancer Radiothér. 2012; 16: 29-33. Ref.: https://goo.gl/2WJbB6
  7. Vogin G. Radiosensitivity, radiocurability and DNA repair. Cancer Radiothér. 2011; 15: 294-306. Ref.: https://goo.gl/RGYSMB
  8. Favaudon V. Radiobiology. Cancer Radiothér. 2000; 4: 333. Ref.: https://goo.gl/WXBst5
  9. Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol. 1989; 62: 679-694. Ref.: https://goo.gl/CqhhjS
  10. Bruzzaniti V, Abate A, Pedrini M, Benassi M, Strigari L, et al. a tool for automatic calculation of biologically equivalent fractionation schedules in radiotherapy using IMRT with a simultaneous integrated boost (SIB) technique. J Exp Clin Cancer Res. 2011; 30: 52. Ref.: https://goo.gl/peFX2V
  11. Bibault JE, Fumagalli I, Diaz O, Faivre JC, Leroy T, et al. The French Society of Young Radiation Oncologists: History, goals and perspective. Reports of Pract Oncol Radiother. 2012; 17: 255-258. Ref.: https://goo.gl/hX8lz8
  12. Gomez-Iturriaga A, Bilbao P, Casquero F, Cacicedo J, Crook J. Smartphones and tablets: Reshaping radiation oncologist’s lives. Reports of Pract Oncol Radiother. 2012; 17: 276-280. Ref.: https://goo.gl/SfUHiQ
  13. Ellis P. Dose, Time and fractionation. A clinical hypothesis. Clin Radiol. 1969; 20: 1-6. Ref.: https://goo.gl/AppW4i
  14. Liversage WE. A critical look at the ret. Br J Radiol. 1971; 44: 91-100. Ref.: https://goo.gl/tZl7lA
  15. Cosset JM. The come-back of hypofractionation? Cancer Radiothér. 2005; 9: 366-373. Ref.: https://goo.gl/ll8eBk
  16. Laszlo A, Rosset A, Hermann F, Ozsahin M, Zouhair A, et al. T.i.d. accelerated radiotherapy alone or alternating with chemotherapy in patients with a locally advanced ORL cancer: analysis of late toxicity. Cancer Radiothér. 2001; 5: 130-137. Ref.: https://goo.gl/wc2H8l
  17. Astrahan M. Some implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation. Med Phys. 2008; 35: 4161-4173. Ref.: https://goo.gl/5F0L8c
  18. Dale RG. Radiobiological assessment of permanent implants using tumor repopulation factors in the linear quadratic model. Br J Radiol. 1989; 62: 241-244. Ref.: https://goo.gl/aa87iu
  19. Thames HD. An incomplete-repair model for survival after fractionated and continuous irradiations. Int J Radiat Biol Relat Stud Phys Chem Med. 1985; 47: 319-339. Ref.: https://goo.gl/ynYp7d
  20. Van Dyk J, Mah K, Keane TJ. Radiation induced lung damage: dose time fractionation consideration. Radiot Onc. 1989; 14: 55-69. Ref.: https://goo.gl/Mi2uRD
  21. Voyant C, Julian D, Roustit R, Biffi K, Marcovici CL. Biological effects and equivalent doses in radiotherapy: a software solution. Rep Pract Oncol Radiother. 2013; 29: 47-55. Ref.: https://goo.gl/5LkkB7

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More