Abstract

Short Communication

Non-invasive physical plasma as an innovative physical approach for the oncological therapy of skeletal sarcomas

Matthias B Stope*

Published: 21 September, 2022 | Volume 6 - Issue 3 | Pages: 018-021

Human osteosarcoma is the most common malignant bone tumor with an annual incidence of two cases per 1 million population. Osteosarcoma account for 60% of all malignant bone tumors occurring in childhood, followed by Ewing’s sarcoma [1-3]

Read Full Article HTML DOI: 10.29328/journal.jro.1001042 Cite this Article Read Full Article PDF

References

  1. Dorfman HD, Czerniak B. Bone cancers. Cancer. 1995 Jan 1;75(1 Suppl):203-10. doi: 10.1002/1097-0142(19950101)75:1+<203::aid-cncr2820751308>3.0.co;2-v. PMID: 8000997.
  2. Klein MJ, Siegal GP. Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol. 2006 Apr;125(4):555-81. doi: 10.1309/UC6K-QHLD-9LV2-KENN. PMID: 16627266.
  3. Meister M, Hölzel D. Bone tumors – soft tissue sarcomas. Recommendations for diagnostics, therapy and aftercare. Guidelines of the German Society for Orthopedics and Orthopedic Surgery (DGOOC) and the Professional Association of Orthopedic Doctors (BVO), "AWMF Guideline Register" No. 033/038. Munich: Munich Tumor Center. 1999.
  4. Lamplot JD, Denduluri S, Qin J, Li R, Liu X, Zhang H, Chen X, Wang N, Pratt A, Shui W, Luo X, Nan G, Deng ZL, Luo J, Haydon RC, He TC, Luu HH. The Current and Future Therapies for Human Osteosarcoma. Curr Cancer Ther Rev. 2013 Feb;9(1):55-77. doi: 10.2174/1573394711309010006. PMID: 26834515; PMCID: PMC4730918.
  5. Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE. Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma. Cancer. 2014 Dec 15;120(24):3987-93. doi: 10.1002/cncr.28936. Epub 2014 Aug 12. PMID: 25116228.
  6. Piperno-Neumann S. Prise en charge des ostéosarcomes en 2009 [Diagnosis and treatment of primary osteosarcoma in 2009]. Bull Cancer. 2010 Jun;97(6):715-21. French. doi: 10.1684/bdc.2010.1123. PMID: 20483711.
  7. van Oosterwijk JG, Anninga JK, Gelderblom H, Cleton-Jansen AM, Bovée JV. Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma. Hematol Oncol Clin North Am. 2013 Oct;27(5):1021-48. doi: 10.1016/j.hoc.2013.07.012. Epub 2013 Aug 26. PMID: 24093174.
  8. Stope MB. Plasma oncology - Physical plasma as innovative tumor therapy. J Cancer Biol. 1:53-56.
  9. Nitsch A, Stope MB. The future therapy of renal cell carcinoma? Non-invasive physical plasma as an innovative oncological therapy modality. J Cancer Ther. 2021; 12:602-610.
  10. Kramer A, Meinke M, Patzelt A, Stope MB, Lademann J, Jacobs K. Perspektiven physikalischer Verfahren der Antiseptik und Desinfektion. Hygiene & Medizin. 2010; 45:39-45
  11. Kletschkus K, Haralambiev L, Mustea A, Bekeschus S, Stope MB. Review of Innovative Physical Therapy Methods: Introduction to the Principles of Cold Physical Plasma. In Vivo. 2020 Nov-Dec;34(6):3103-3107. doi: 10.21873/invivo.12143. PMID: 33144413; PMCID: PMC7811668.
  12. Weiss M, Gümbel D, Hanschmann EM, Mandelkow R, Gelbrich N, Zimmermann U, Walther R, Ekkernkamp A, Sckell A, Kramer A, Burchardt M, Lillig CH, Stope MB. Cold Atmospheric Plasma Treatment Induces Anti-Proliferative Effects in Prostate Cancer Cells by Redox and Apoptotic Signaling Pathways. PLoS One. 2015 Jul 1;10(7):e0130350. doi: 10.1371/journal.pone.0130350. PMID: 26132846; PMCID: PMC4488447.
  13. Schmidt A, von Woedtke T, Bekeschus S. Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin. Oxid Med Cell Longev. 2016;2016:9816072. doi: 10.1155/2016/9816072. Epub 2016 Feb 4. PMID: 26966508; PMCID: PMC4757748.
  14. Gümbel D, Gelbrich N, Weiss M, Napp M, Daeschlein G, Sckell A, Ender SA, Kramer A, Burchardt M, Ekkernkamp A, Stope MB. New Treatment Options for Osteosarcoma - Inactivation of Osteosarcoma Cells by Cold Atmospheric Plasma. Anticancer Res. 2016 Nov;36(11):5915-5922. doi: 10.21873/anticanres.11178. PMID: 27793916.
  15. Heinlin J, Isbary G, Stolz W, Morfill G, Landthaler M, Shimizu T, Steffes B, Nosenko T, Zimmermann J, Karrer S. Plasma applications in medicine with a special focus on dermatology. J Eur Acad Dermatol Venereol. 2011 Jan;25(1):1-11. doi: 10.1111/j.1468-3083.2010.03702.x. PMID: 20497290.
  16. Gümbel D, Bekeschus S, Gelbrich N, Napp M, Ekkernkamp A, Kramer A, Stope MB. Cold Atmospheric Plasma in the Treatment of Osteosarcoma. Int J Mol Sci. 2017 Sep 19;18(9):2004. doi: 10.3390/ijms18092004. PMID: 28925941; PMCID: PMC5618653.
  17. Gümbel D, Daeschlein G, Ekkernkamp A, Kramer A, Stope MB. Cold atmospheric plasma in orthopaedic and urologic tumor therapy. GMS Hyg Infect Control. 2017 Aug 8;12:Doc10. doi: 10.3205/dgkh000295. PMID: 28840090; PMCID: PMC5550744.
  18. Weiss M, Daeschlein G, Kramer A, Burchardt M, Brucker S, Wallwiener D, Stope MB. Virucide properties of cold atmospheric plasma for future clinical applications. J Med Virol. 2017 Jun;89(6):952-959. doi: 10.1002/jmv.24701. Epub 2017 Feb 13. PMID: 27696466.
  19. Jacoby JM, Strakeljahn S, Nitsch A, Bekeschus S, Hinz P, Mustea A, Ekkernkamp A, Tzvetkov MV, Haralambiev L, Stope MB. An Innovative Therapeutic Option for the Treatment of Skeletal Sarcomas: Elimination of Osteo- and Ewing's Sarcoma Cells Using Physical Gas Plasma. Int J Mol Sci. 2020 Jun 23;21(12):4460. doi: 10.3390/ijms21124460. PMID: 32585948; PMCID: PMC7352911.
  20. Nitsch A, Strakeljahn S, Jacoby JM, Sieb KF, Mustea A, Bekeschus S, Ekkernkamp A, Stope MB, Haralambiev L. New Approach against Chondrosoma Cells-Cold Plasma Treatment Inhibits Cell Motility and Metabolism, and Leads to Apoptosis. Biomedicines. 2022 Mar 17;10(3):688. doi: 10.3390/biomedicines10030688. PMID: 35327489; PMCID: PMC8945812.
  21. Gümbel D, Gelbrich N, Napp M, Daeschlein G, Kramer A, Sckell A, Burchardt M, Ekkernkamp A, Stope MB. Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment. Anticancer Res. 2017 Mar;37(3):1031-1038. doi: 10.21873/anticanres.11413. PMID: 28314261.
  22. Schütz CS, Stope MB, Bekeschus S. H2A.X Phosphorylation in Oxidative Stress and Risk Assessment in Plasma Medicine. Oxid Med Cell Longev. 2021 Dec 13;2021:2060986. doi: 10.1155/2021/2060986. PMID: 34938381; PMCID: PMC8687853.
  23. Haralambiev L, Wien L, Gelbrich N, Kramer A, Mustea A, Burchardt M, Ekkernkamp A, Stope MB, Gümbel D. Effects of Cold Atmospheric Plasma on the Expression of Chemokines, Growth Factors, TNF Superfamily Members, Interleukins, and Cytokines in Human Osteosarcoma Cells. Anticancer Res. 2019 Jan;39(1):151-157. doi: 10.21873/anticanres.13091. PMID: 30591452.
  24. Haralambiev L, Nitsch A, Einenkel R, Muzzio DO, Gelbrich N, Burchardt M, Zygmunt M, Ekkernkamp A, Stope MB, Gümbel D. The Effect of Cold Atmospheric Plasma on the Membrane Permeability of Human Osteosarcoma Cells. Anticancer Res. 2020 Feb;40(2):841-846. doi: 10.21873/anticanres.14016. PMID: 32014927.
  25. Haralambiev L, Neuffer O, Nitsch A, Kross NC, Bekeschus S, Hinz P, Mustea A, Ekkernkamp A, Gümbel D, Stope MB. Inhibition of Angiogenesis by Treatment with Cold Atmospheric Plasma as a Promising Therapeutic Approach in Oncology. Int J Mol Sci. 2020 Sep 26;21(19):7098. doi: 10.3390/ijms21197098. PMID: 32993057; PMCID: PMC7582386.
  26. Haralambiev L, Wien L, Gelbrich N, Lange J, Bakir S, Kramer A, Burchardt M, Ekkernkamp A, Gümbel D, Stope MB. Cold atmospheric plasma inhibits the growth of osteosarcoma cells by inducing apoptosis, independent of the device used. Oncol Lett. 2020 Jan;19(1):283-290. doi: 10.3892/ol.2019.11115. Epub 2019 Nov 19. PMID: 31897140; PMCID: PMC6924118.
  27. Shah MA, Rogoff HA. Implications of reactive oxygen species on cancer formation and its treatment. Semin Oncol. 2021 Jun;48(3):238-245. doi: 10.1053/j.seminoncol.2021.05.002. Epub 2021 Aug 4. PMID: 34548190.
  28. Koensgen D, Besic I, Gümbel D, Kaul A, Weiss M, Diesing K, Kramer A, Bekeschus S, Mustea A, Stope MB. Cold Atmospheric Plasma (CAP) and CAP-Stimulated Cell Culture Media Suppress Ovarian Cancer Cell Growth - A Putative Treatment Option in Ovarian Cancer Therapy. Anticancer Res. 2017 Dec;37(12):6739-6744. doi: 10.21873/anticanres.12133. PMID: 29187451.
  29. Eggers B, Stope MB, Marciniak J, Mustea A, Deschner J, Nokhbehsaim M, Kramer FJ. Modulation of Inflammatory Responses by a Non-Invasive Physical Plasma Jet during Gingival Wound Healing. Cells. 2022 Sep 2;11(17):2740. doi: 10.3390/cells11172740. PMID: 36078148; PMCID: PMC9454534.
  30. Marzi J, Stope MB, Henes M, Koch A, Wenzel T, Holl M, Layland SL, Neis F, Bösmüller H, Ruoff F, Templin M, Krämer B, Staebler A, Barz J, Carvajal Berrio DA, Enderle M, Loskill PM, Brucker SY, Schenke-Layland K, Weiss M. Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia. Cancers (Basel). 2022 Apr 12;14(8):1933. doi: 10.3390/cancers14081933. PMID: 35454839; PMCID: PMC9027888.
  31. Partecke LI, Evert K, Haugk J, Doering F, Normann L, Diedrich S, Weiss FU, Evert M, Huebner NO, Guenther C, Heidecke CD, Kramer A, Bussiahn R, Weltmann KD, Pati O, Bender C, von Bernstorff W. Tissue tolerable plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo. BMC Cancer. 2012 Oct 15;12:473. doi: 10.1186/1471-2407-12-473. PMID: 23066891; PMCID: PMC3598726.
  32. Heinlin J, Isbary G, Stolz W, Morfill G, Landthaler M, Shimizu T, Steffes B, Nosenko T, Zimmermann J, Karrer S. Plasma applications in medicine with a special focus on dermatology. J Eur Acad Dermatol Venereol. 2011 Jan;25(1):1-11. doi: 10.1111/j.1468-3083.2010.03702.x. PMID: 20497290.
  33. Isbary G, Morfill G, Schmidt HU, Georgi M, Ramrath K, Heinlin J, Karrer S, Landthaler M, Shimizu T, Steffes B, Bunk W, Monetti R, Zimmermann JL, Pompl R, Stolz W. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br J Dermatol. 2010 Jul;163(1):78-82. doi: 10.1111/j.1365-2133.2010.09744.x. Epub 2010 Mar 5. PMID: 20222930.
  34. Linde J, Liedtke KR, Matthes R, Kramer A, Heidecke CD, Partecke LI. Repeated cold atmospheric plasma application to intact skin does not cause sensitization in a standardized murine model. Plasma. 2017; 7:383-393
  35. Schmidt A, Woedtke TV, Stenzel J, Lindner T, Polei S, Vollmar B, Bekeschus S. One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet. Int J Mol Sci. 2017 Apr 19;18(4):868. doi: 10.3390/ijms18040868. PMID: 28422070; PMCID: PMC5412449.
  36. Kluge S, Bekeschus S, Bender C, Benkhai H, Sckell A, Below H, Stope MB, Kramer A. Investigating the Mutagenicity of a Cold Argon-Plasma Jet in an HET-MN Model. PLoS One. 2016 Sep 1;11(9):e0160667. doi: 10.1371/journal.pone.0160667. PMID: 27584003; PMCID: PMC5008819.
  37. Wende K, Bekeschus S, Schmidt A, Jatsch L, Hasse S, Weltmann KD, Masur K, von Woedtke T. Risk assessment of a cold argon plasma jet in respect to its mutagenicity. Mutat Res Genet Toxicol Environ Mutagen. 2016 Mar;798-799:48-54. doi: 10.1016/j.mrgentox.2016.02.003. Epub 2016 Feb 23. PMID: 26994493.
  38. Boehm D, Heslin C, Cullen PJ, Bourke P. Cytotoxic and mutagenic potential of solutions exposed to cold atmospheric plasma. Sci Rep. 2016 Feb 24;6:21464. doi: 10.1038/srep21464. PMID: 26908060; PMCID: PMC4764912.

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