Figure 6

Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications

Loutfy H Madkour*

Published: 04 March, 2021 | Volume 5 - Issue 1 | Pages: 005-034

Positron emission tomography (PET) and single-photon emission computed tomography (SPECT). (a) A schematic illustration of the basic principles of in vivo PET imaging. In this technique, the radioactive isotope-labeled RNAi therapeutics is injected into animals. Positrons are emitted from the isotopes associating with electrons, which cause annihilation and subsequent production of two gamma (γ) rays. The two high-energy γ rays are traveling at 180° from each other. Then the γ rays are received by detector array with electrical signals and finally converted into tomographic images. (b) Another schematic illustration of the basic principle of in vivo SPECT imaging. First, the radioactive isotopes-labeled RNAi therapeutics is administered into the mouse to emit γ rays. The γ rays produced by isotopes in SPECT do not travel in opposite directions, instead, are collected by detector array that rotates around animals, while any diagonally incident γ rays are filtered by collimator. The γ rays received by detector array are converted and reconstructed into tomographic images.

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Figure 6:

Positron emission tomography (PET) and single-photon emission computed tomography (SPECT). (a) A schematic illustration of the basic principles of in vivo PET imaging. In this technique, the radioactive isotope-labeled RNAi therapeutics is injected into animals. Positrons are emitted from the isotopes associating with electrons, which cause annihilation and subsequent production of two gamma (γ) rays. The two high-energy γ rays are traveling at 180° from each other. Then the γ rays are received by detector array with electrical signals and finally converted into tomographic images. (b) Another schematic illustration of the basic principle of in vivo SPECT imaging. First, the radioactive isotopes-labeled RNAi therapeutics is administered into the mouse to emit γ rays. The γ rays produced by isotopes in SPECT do not travel in opposite directions, instead, are collected by detector array that rotates around animals, while any diagonally incident γ rays are filtered by collimator. The γ rays received by detector array are converted and reconstructed into tomographic images.

Read Full Article HTML DOI: 10.29328/journal.jro.1001035 Cite this Article Read Full Article PDF

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